Mammalian G protein-coupled receptors (GPCRs) constitute a superfamily of diverse proteins with hundreds of members. All members have seven transmembrane domains but, on the basis of shared sequence motifs, they are grouped into four classes: A, B, C, and F/S. GPCRs act as receptors for a multitude of different signals. One major group, referred to as chemosensory GPCRs (csGPCRs), are receptors for sensory signals of external origin that are sensed as odors, pheromones, or tastes. Most other GPCRs respond to endogenous signals, such as peptides, lipids, neurotransmitters, or nucleotides. These GPCRs, the subject of this report, are involved in numerous physiological processes, including the regulation of neuronal excitability, metabolism, reproduction, development, hormonal homeostasis, and behavior. Considering that endogenous ligands are required for regulating these processes, in this report, we refer to this group of GPCRs as “endoGPCRs.”. GPR156 (G protein-coupled receptor 156), is a human gene which encodes a G protein-coupled receptor belonging to metabotropic glutamate receptor subfamily. By sequence homology, this gene was proposed as being a possible GABAB receptor subunit, however when expressed in cells alone or with other GABAB subunits, no response to GABAB ligands could be detected. Therefore, the function of this protein remains to be elucidated. In vitro studies on GPR156 constitutive activity revealed a high level of basal activation and coupling with members of the Gi/Go heterotrimeric G protein family. Here you can see a cryoEM structure of the human G-protein receptor GPR156 (PDB code: 8IEQ)

#molecularart ... #receptor ... #membrane ... #gcoupled ... #gpr156 ... #cryoem

Structure rendered with @proteinimaging, represented with @corelphotopaint and post-processed by @stylar.ai_official